We work on mathematical and computational modeling of the mechanical response of soft tissues. In particular, we develop energy-based constitutive laws for passive and active biological structures, tacking into account microstructures features. Specific organs of interest are skin, cornea, bone, vessels, and the gastrointestinal wall. We implement experimental-based formulations into finite element models built into image-based computational domains.
Collaborators: A. Pandolfi, M. Vasta, M. Marino, G. Vairo, C.J. Cyron
Related publications:
C. Falcinelli, A. Di Martino, A. Gizzi, G. Vairo, and V. Denaro. Fracture risk assessment in metastatic femurs: A patient-specific CT-based FEM approach. Meccanica (2019) doi:10.1007/s11012-019-01097-x
A. Pandolfi, A. Gizzi, M. Vasta. A microstructural model of crosslink interaction between collagen fibrils in the human cornea. Phil. Trans. R. Soc. A 377:20180079 (2019). doi.org/10.1098/rsta.2018.0079
C. Falcinelli, A. Di Martino, A. Gizzi, G. Vairo, and V. Denaro. Mechanical behavior of metastatic femurs through patient-specific computational models accounting for bone-metastasis interaction. J. Mech. Behav. Biomed. Mat. 93:9–22 (2019). doi.org/10.1016/j.jmbbm.2019.01.014
S. Brandstaeter, A. Gizzi, S.L. Fuchs, A.M. Gebauer, R.C. Aydin, C.J. Cyron. Computational model of gastric motility with active-strain electromechanics. Z. Angew. Math. Mech. (ZAMM) 98:2177–2197 (2018). doi.org/10.1002/zamm.201800166
M. Vasta, A. Gizzi, A. Pandolfi. A spectral decomposition approach for the mechanical statistical characterization of distributed fiber-reinforced tissues. Int. J. Nonlin. Mech. 106:258–265 (2018). doi.org/10.1016/j.ijnonlinmec.2018.06.010
A. Gizzi∗, A. Pandolfi, and M. Vasta. A generalized statistical approach for modeling fiber-reinforced materials. J. Eng. Math. 109:211–226 (2018).
P. Simone, C. Carusi, F. Segreto, R. Iannuzzi, S. Buscaglione, A. Gizzi, S.M. Giannitelli, A. Rainer, S. Filippi, and P. Persichetti. Post-bariatric brachioplasty with postero-medial scar: physical model, technical refinements and clinical outcomes. Plast. Reconstr. Surg. 141:344–353 (2018).
D. Bianchi, E. Monaldo, A. Gizzi, M. Marino, S. Filippi, and G. Vairo. A FSI computational framework for vascular physiopathology: A novel flow-tissue multiscale strategy. Med. Eng. Phys. 47:25–37 (2017). DOI: 10.1016/j.medengphy.2017.06.028
A. Pandolfi, A. Gizzi, and M. Vasta. Visco-electro-elastic models of fiber-distributed active tissues. Meccanica. 52:3399–3415 (2017). DOI: 10.1007/s11012-017-0622-4
A. Pandolfi, A. Gizzi, and M. Vasta. Coupled electro-mechanical models of fiber-distributed active tissues. J. Biomech. 49:2436–2444 (2016). DOI:10.1016/j.jbiomech.2016.01.038
A. Gizzi, A. Pandolfi, and M. Vasta. Statistical characterization of the anisotropic strain energy in soft materials with distributed fibers. Mech. Mater. 92 : 119 − 138 (2016). DOI: 10.1016/j.mechmat.2015.09.008
A. Gizzi∗, M. Vasta, and A. Pandolfi. Modeling collagen recruitment in hyperelastic bio-material models with statistical distribution of the fiber orientation. Int. J. Eng. Sci. 78 : 48 − 60 (2014). DOI: http://dx.doi.org/10.1016/j.ijengsci.2014.02.008
A. Altomare, A. Gizzi, M.P.L. Guarino, S. Cocca, A. Loppini, M. Dipaola, R. Alloni, M. Cicala, S. Filippi. Experimental evidences and mathematical modeling of thermal effects on human colonic smooth muscle con- tractility. Am. J. Physiol. 307 : G77 − G88 (2014).
A. Gizzi∗, C. Cherubini, N. Pomella, P. Persichetti, M. Vasta, and S. Filippi. Computational modeling and stress analysis of columellar biomechanics. J. Mech. Behav. Biomed. Mat. 15 : 46 − 58 (2012). DOI: 10.1016/j.jmbbm.2012.06.006
A. Gizzi, C. Cherubini, S. Migliori, R. Portuesi, R. Alloni, and S. Filippi. On the electrical intestine turbulence induced by temperature changes. Phys. Biol. 7 : 016011 (2010). DOI:10.1088/1478-3975/7/1/016011
