We work on mathematical and computational modeling of the mechanical response of soft tissues. In particular, we develop energy-based constitutive laws for passive and active biological structures, tacking into account microstructures features. Specific organs of interest are skin, cornea, bone, vessels, and the gastrointestinal wall. We implement experimental-based formulations into finite element models built into image-based computational domains.

Collaborators: A. Pandolfi, M. Vasta, M. Marino, G. Vairo, C.J. Cyron

Related publications:

C. Falcinelli, A. Di Martino, A. Gizzi, G. Vairo, and V. Denaro. Fracture risk assessment in metastatic femurs: A patient-specific CT-based FEM approach. Meccanica (2019) doi:10.1007/s11012-019-01097-x

A. Pandolfi, A. Gizzi, M. Vasta. A microstructural model of crosslink interaction between collagen fibrils in the human cornea. Phil. Trans. R. Soc. A 377:20180079 (2019).

C. Falcinelli, A. Di Martino, A. Gizzi, G. Vairo, and V. Denaro. Mechanical behavior of metastatic femurs through patient-specific computational models accounting for bone-metastasis interaction. J. Mech. Behav. Biomed. Mat. 93:9–22 (2019).

S. Brandstaeter, A. Gizzi, S.L. Fuchs, A.M. Gebauer, R.C. Aydin, C.J. Cyron. Computational model of gastric motility with active-strain electromechanics. Z. Angew. Math. Mech. (ZAMM) 98:2177–2197 (2018).

M. Vasta, A. Gizzi, A. Pandolfi. A spectral decomposition approach for the mechanical statistical characterization of distributed fiber-reinforced tissues. Int. J. Nonlin. Mech. 106:258–265 (2018).

A. Gizzi∗, A. Pandolfi, and M. Vasta. A generalized statistical approach for modeling fiber-reinforced materials. J. Eng. Math. 109:211–226 (2018).

P. Simone, C. Carusi, F. Segreto, R. Iannuzzi, S. Buscaglione, A. Gizzi, S.M. Giannitelli, A. Rainer, S. Filippi, and P. Persichetti. Post-bariatric brachioplasty with postero-medial scar: physical model, technical refinements and clinical outcomes. Plast. Reconstr. Surg. 141:344–353 (2018).

D. Bianchi, E. Monaldo, A. Gizzi, M. Marino, S. Filippi, and G. Vairo. A FSI computational framework for vascular physiopathology: A novel flow-tissue multiscale strategy. Med. Eng. Phys. 47:25–37 (2017). DOI: 10.1016/j.medengphy.2017.06.028

A. Pandolfi, A. Gizzi, and M. Vasta. Visco-electro-elastic models of fiber-distributed active tissues. Meccanica. 52:3399–3415 (2017). DOI: 10.1007/s11012-017-0622-4

A. Pandolfi, A. Gizzi, and M. Vasta. Coupled electro-mechanical models of fiber-distributed active tissues. J. Biomech. 49:2436–2444 (2016). DOI:10.1016/j.jbiomech.2016.01.038

A. Gizzi, A. Pandolfi, and M. Vasta. Statistical characterization of the anisotropic strain energy in soft materials with distributed fibers. Mech. Mater. 92 : 119 − 138 (2016). DOI: 10.1016/j.mechmat.2015.09.008

A. Gizzi∗, M. Vasta, and A. Pandolfi. Modeling collagen recruitment in hyperelastic bio-material models with statistical distribution of the fiber orientation. Int. J. Eng. Sci. 78 : 48 − 60 (2014). DOI:

A. Altomare, A. Gizzi, M.P.L. Guarino, S. Cocca, A. Loppini, M. Dipaola, R. Alloni, M. Cicala, S. Filippi. Experimental evidences and mathematical modeling of thermal effects on human colonic smooth muscle con- tractility. Am. J. Physiol. 307 : G77 − G88 (2014).

A. Gizzi∗, C. Cherubini, N. Pomella, P. Persichetti, M. Vasta, and S. Filippi. Computational modeling and stress analysis of columellar biomechanics. J. Mech. Behav. Biomed. Mat. 15 : 46 − 58 (2012). DOI: 10.1016/j.jmbbm.2012.06.006

A. Gizzi, C. Cherubini, S. Migliori, R. Portuesi, R. Alloni, and S. Filippi. On the electrical intestine turbulence induced by temperature changes. Phys. Biol. 7 : 016011 (2010). DOI:10.1088/1478-3975/7/1/016011